The Asthma Center

Chronic sinusitis and antibiotics

There are no national guidelines for antibiotic treatment for chronic sinusitis. Specialists use guidelines similar to those for acute sinusitis. Physicians may also prescribe clindamycin (Cleocin®) and/or metronidazole (Flagyl®) to treat suspected anaerobic infections. First line treatment choices include amoxicillin/clavulanate (Augmentin®) or cefuroxime (Ceftin®) along with clindamycin (Cleocin®) or metronidazole (Flagyl®). If you are allergic to penicillin, the macrolide (Zithromax®, erythromycin, telithromycin, Biaxin®), fluoroquinolone (Tequin®, Levaquin®, Avelox® and Factive®), or ketolide (Ketek®) classes of antibiotics are used. Antibiotic treatment is prescribed for 6 weeks and often longer.

There are some antibiotic treatment options specifically used for chronic sinusitis:
Nasal and Nebulized Antibiotics
Intravenous Antibiotics